Firmino hits a major milestone & Reds look to extend a 17-year run in Europe
The teams met in last season’s group stage with both games resulting in a 1-0 win for the home side.
They met in Matchday 2 in Naples with Lorenzo Insigne sealing victory in the last minute.
Liverpool qualified from the group despite losing all three away fixtures.
They also met in the 2010/11 Europa League group stage, with the teams drawing 0-0 in Italy before Liverpool won 3-1 at Anfield, with Steven Gerrard scoring a 15-minute hat-trick.
Reds vs. Serie A
In all games the Reds have won 13, drawn three and lost 12 of the 28 clashes with teams from Italy.
In those nine visits the Reds have kept six clean sheets.
Scores to settle
Jurgen Klopp has faced Italian clubs in 10 games during his managerial career, winning four and losing six.
On their only two previous visits to the San Paolo, Liverpool have failed to score.
Take your pick
If he plays tonight, Firmino will make his 200th appearance for Liverpool.
Mane has scored six goals in his six appearances this season and has 23 in his last 29 for the Reds.
Salah has found the net 11 times in his last 17 Liverpool games.
Steven Gerrard (30) has scored more European Cup goals for Liverpool than any other player. Next on the list are Salah 16, Firmino 15 and Mane 14. (Ian Rush also has 14).
That’s why we’re the Unbearables
108 days after their Champions League success the Reds begin this season’s challenge.
Liverpool are three goals short of recording 450 in all competitions under Jurgen Klopp.
Liverpool are unbeaten in 13 opening group games of a European campaign (eight wins and five draws) since losing at Valencia in 2002.
Napoli state of play
The Italian outfit have finished second in three of the last four Serie A campaigns, including each of the last two.
He was the second manager after Bob Paisley to win the European Cup three times.
Napoli have played three times this season. Their opening two Serie A games produced 4-3 results, a win at Fiorentina followed by a defeat at Juventus. Last weekend they beat Sampdoria 2-0 at home with Dries Mertens scoring both.
Scorers this season
Liverpool: Mane 6, Salah 4, Firmino 2, Matip 2, Origi 1, van Dijk 1, own goals 2.
Napoli: Mertens 3, Insigne 2, Callejon 1, Di Lorenzo 1, Lozano 1, Manolas 1.